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High-throughput discovery of broad-spectrum peptide antibiotics

Membrane-permeabilizing peptide antibiotics are an underutilized weapon in the battle against drug-resistant microorganisms. This is true, in part, because of the bottleneck caused by the lack of explicit design principles and the paucity of simple high-throughput methods for selection. In this work...

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Autori principali: Rathinakumar, Ramesh, Wimley, William C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Federation of American Societies for Experimental Biology 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2923358/
https://ncbi.nlm.nih.gov/pubmed/20410445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.10-157040
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