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Broad-spectrum Antimicrobial Peptides by Rational Combinatorial Design and High-throughput Screening: The Importance of Interfacial Activity*

We recently described ten peptides selected from a 16,384-member combinatorial library based on their ability to permeabilize synthetic lipid vesicles in vitro (Rathinakumar R and Wimley WC, J. Am. Chem. Soc. 2008, 130, 9849-9858). These peptides did not share a common sequence motif, length or net...

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書誌詳細
主要な著者: Rathinakumar, Ramesh, Walkenhorst, William F., Wimley, William C.
フォーマット: Artigo
言語:Inglês
出版事項: 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2935846/
https://ncbi.nlm.nih.gov/pubmed/19445503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja8093247
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