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Determining the mechanism of membrane permeabilizing peptides: Identification of potent, equilibrium pore-formers

To enable selection and characterization of highly potent pore-forming peptides, we developed a set of novel assays to probe 1) the potency of peptide pores at very low peptide concentration; 2) the presence or absence of pores in membranes after equilibration; 3) the interbilayer exchangeability of...

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Bibliographic Details
Main Authors: Krauson, Aram J., He, Jing, Wimley, William C.
Format: Artigo
Language:Inglês
Published: 2012
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3428429/
https://ncbi.nlm.nih.gov/pubmed/22365969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2012.02.009
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