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Structural analyses of covalent enzyme-substrate analogue complexes reveal strengths and limitations of de novo enzyme design
We report the cocrystal structures of a computationally designed and experimentally optimized retro-aldol enzyme with covalently bound substrate analogs. The structure with covalently bound substrate analog is similar but not identical to the design model, with an RMSD over the active site residues...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3440004/ https://ncbi.nlm.nih.gov/pubmed/22075445 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.10.043 |
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