Chargement en cours...
Structural analyses of covalent enzyme-substrate analogue complexes reveal strengths and limitations of de novo enzyme design
We report the cocrystal structures of a computationally designed and experimentally optimized retro-aldol enzyme with covalently bound substrate analogs. The structure with covalently bound substrate analog is similar but not identical to the design model, with an RMSD over the active site residues...
Enregistré dans:
| Auteurs principaux: | , , , , , , , , , |
|---|---|
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2011
|
| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3440004/ https://ncbi.nlm.nih.gov/pubmed/22075445 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.10.043 |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|