De Novo Computational Design of Retro-Aldol Enzymes

The creation of enzymes capable of catalyzing any desired chemical reaction is a grand challenge for computational protein design. Using new algorithms that rely on hashing techniques to construct active sites for multistep reactions, we designed retro-aldolases that use four different catalytic mot...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Jiang, Lin, Althoff, Eric A., Clemente, Fernando R., Doyle, Lindsey, Röthlisberger, Daniela, Zanghellini, Alexandre, Gallaher, Jasmine L., Betker, Jamie L., Tanaka, Fujie, Barbas, Carlos F., Hilvert, Donald, Houk, Kendall N., Stoddard, Barry L., Baker, David
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2008
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3431203/
https://ncbi.nlm.nih.gov/pubmed/18323453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1152692
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