De Novo Computational Design of Retro-Aldol Enzymes

The creation of enzymes capable of catalyzing any desired chemical reaction is a grand challenge for computational protein design. Using new algorithms that rely on hashing techniques to construct active sites for multistep reactions, we designed retro-aldolases that use four different catalytic mot...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Hoofdauteurs: Jiang, Lin, Althoff, Eric A., Clemente, Fernando R., Doyle, Lindsey, Röthlisberger, Daniela, Zanghellini, Alexandre, Gallaher, Jasmine L., Betker, Jamie L., Tanaka, Fujie, Barbas, Carlos F., Hilvert, Donald, Houk, Kendall N., Stoddard, Barry L., Baker, David
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2008
Onderwerpen:
Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3431203/
https://ncbi.nlm.nih.gov/pubmed/18323453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1152692
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items