De Novo Computational Design of Retro-Aldol Enzymes

The creation of enzymes capable of catalyzing any desired chemical reaction is a grand challenge for computational protein design. Using new algorithms that rely on hashing techniques to construct active sites for multistep reactions, we designed retro-aldolases that use four different catalytic mot...

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Detalhes bibliográficos
Main Authors: Jiang, Lin, Althoff, Eric A., Clemente, Fernando R., Doyle, Lindsey, Röthlisberger, Daniela, Zanghellini, Alexandre, Gallaher, Jasmine L., Betker, Jamie L., Tanaka, Fujie, Barbas, Carlos F., Hilvert, Donald, Houk, Kendall N., Stoddard, Barry L., Baker, David
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3431203/
https://ncbi.nlm.nih.gov/pubmed/18323453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1152692
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