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Robust design and optimization of retroaldol enzymes
Enzyme catalysts of a retroaldol reaction have been generated by computational design using a motif that combines a lysine in a nonpolar environment with water-mediated stabilization of the carbinolamine hydroxyl and β-hydroxyl groups. Here, we show that the design process is robust and repeatable,...
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| Auteurs principaux: | , , , , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Wiley Subscription Services, Inc., A Wiley Company
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3403469/ https://ncbi.nlm.nih.gov/pubmed/22407837 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2059 |
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