Robust design and optimization of retroaldol enzymes

Enzyme catalysts of a retroaldol reaction have been generated by computational design using a motif that combines a lysine in a nonpolar environment with water-mediated stabilization of the carbinolamine hydroxyl and β-hydroxyl groups. Here, we show that the design process is robust and repeatable,...

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Bibliografski detalji
Glavni autori: Althoff, Eric A, Wang, Ling, Jiang, Lin, Giger, Lars, Lassila, Jonathan K, Wang, Zhizhi, Smith, Matthew, Hari, Sanjay, Kast, Peter, Herschlag, Daniel, Hilvert, Donald, Baker, David
Format: Artigo
Jezik:Inglês
Izdano: Wiley Subscription Services, Inc., A Wiley Company 2012
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Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3403469/
https://ncbi.nlm.nih.gov/pubmed/22407837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2059
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