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Mevalonate Analogues as Substrates of Enzymes in the Isoprenoid Biosynthetic Pathway of Streptococcus pneumoniae

Survival of the human pathogen Streptococcus pneumoniae requires a functional mevalonate pathway, which produces isopentenyl diphosphate, the essential building block of isoprenoids. Flux through this pathway appears to be regulated at the mevalonate kinase (MK) step, which is strongly feedback-inhi...

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Detalhes bibliográficos
Main Authors: Kudoh, Takashi, Park, Chan Sun, Lefurgy, Scott T., Sun, Meihao, Michels, Theodore, Leyh, Thomas S., Silverman, Richard B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2842986/
https://ncbi.nlm.nih.gov/pubmed/20056424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.12.050
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