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Mevalonate Analogues as Substrates of Enzymes in the Isoprenoid Biosynthetic Pathway of Streptococcus pneumoniae

Survival of the human pathogen Streptococcus pneumoniae requires a functional mevalonate pathway, which produces isopentenyl diphosphate, the essential building block of isoprenoids. Flux through this pathway appears to be regulated at the mevalonate kinase (MK) step, which is strongly feedback-inhi...

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Main Authors: Kudoh, Takashi, Park, Chan Sun, Lefurgy, Scott T., Sun, Meihao, Michels, Theodore, Leyh, Thomas S., Silverman, Richard B.
格式: Artigo
語言:Inglês
出版: 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2842986/
https://ncbi.nlm.nih.gov/pubmed/20056424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.12.050
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