Engineering domain fusion chimeras from I-OnuI family LAGLIDADG homing endonucleases

Although engineered LAGLIDADG homing endonucleases (LHEs) are finding increasing applications in biotechnology, their generation remains a challenging, industrial-scale process. As new single-chain LAGLIDADG nuclease scaffolds are identified, however, an alternative paradigm is emerging: identificat...

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Main Authors: Baxter, Sarah, Lambert, Abigail R., Kuhar, Ryan, Jarjour, Jordan, Kulshina, Nadia, Parmeggiani, Fabio, Danaher, Patrick, Gano, Jacob, Baker, David, Stoddard, Barry L., Scharenberg, Andrew M.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2012
Teme:
Nucleic Acid Enzymes
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3439895/
https://ncbi.nlm.nih.gov/pubmed/22684507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks502
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