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Immunosuppression Enhances Oncolytic Adenovirus Replication and Antitumor Efficacy in the Syrian Hamster Model

We recently described an immunocompetent Syrian hamster model for oncolytic adenoviruses (Ads) that permits virus replication in tumor cells as well as some normal tissues. This model allows exploration of interactions between the virus, tumor, normal organs, and host immune system that could not be...

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Détails bibliographiques
Auteurs principaux: Thomas, Maria A, Spencer, Jacqueline F, Toth, Karoly, Sagartz, John E, Phillips, Nancy J, Wold, William SM
Format: Artigo
Langue:Inglês
Publié: 2008
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3437752/
https://ncbi.nlm.nih.gov/pubmed/18665155
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