Methylglyoxal Activates Nociceptors through Transient Receptor Potential Channel A1 (TRPA1): A POSSIBLE MECHANISM OF METABOLIC NEUROPATHIES

Neuropathic pain can develop as an agonizing sequela of diabetes mellitus and chronic uremia. A chemical link between both conditions of altered metabolism is the highly reactive compound methylglyoxal (MG), which accumulates in all cells, in particular neurons, and leaks into plasma as an index of...

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Hlavní autoři: Eberhardt, Mirjam J., Filipovic, Milos R., Leffler, Andreas, de la Roche, Jeanne, Kistner, Katrin, Fischer, Michael J., Fleming, Thomas, Zimmermann, Katharina, Ivanovic-Burmazovic, Ivana, Nawroth, Peter P., Bierhaus, Angelika, Reeh, Peter W., Sauer, Susanne K.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Neurobiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436587/
https://ncbi.nlm.nih.gov/pubmed/22740698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.328674
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