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Methylglyoxal Evokes Pain by Stimulating TRPA1

Diabetic neuropathy is a severe complication of long-standing diabetes and one of the major etiologies of neuropathic pain. Diabetes is associated with an increased formation of reactive oxygen species and the electrophilic dicarbonyl compound methylglyoxal (MG). Here we show that MG stimulates hete...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Andersson, David A., Gentry, Clive, Light, Emily, Vastani, Nisha, Vallortigara, Julie, Bierhaus, Angelika, Fleming, Thomas, Bevan, Stuart
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3805573/
https://ncbi.nlm.nih.gov/pubmed/24167592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0077986
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