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Clioquinol and pyrithione activate TRPA1 by increasing intracellular Zn(2+)
The antifungal and amoebicidal drug clioquinol (CQ) was withdrawn from the market when it was linked to an epidemic of subacute myelo-optico-neuropathy (SMON). Clioquinol exerts its anti-parasitic actions by acting as a Cu/Zn chelator and ionophore. Here we show that local injections of CQ produce m...
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| Hoofdauteurs: | , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
National Academy of Sciences
2009
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2688854/ https://ncbi.nlm.nih.gov/pubmed/19416844 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0812675106 |
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