Methylglyoxal Activates Nociceptors through Transient Receptor Potential Channel A1 (TRPA1): A POSSIBLE MECHANISM OF METABOLIC NEUROPATHIES

Neuropathic pain can develop as an agonizing sequela of diabetes mellitus and chronic uremia. A chemical link between both conditions of altered metabolism is the highly reactive compound methylglyoxal (MG), which accumulates in all cells, in particular neurons, and leaks into plasma as an index of...

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Detalhes bibliográficos
Main Authors: Eberhardt, Mirjam J., Filipovic, Milos R., Leffler, Andreas, de la Roche, Jeanne, Kistner, Katrin, Fischer, Michael J., Fleming, Thomas, Zimmermann, Katharina, Ivanovic-Burmazovic, Ivana, Nawroth, Peter P., Bierhaus, Angelika, Reeh, Peter W., Sauer, Susanne K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436587/
https://ncbi.nlm.nih.gov/pubmed/22740698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.328674
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