TRPA1 and TRPV1 are required for lidocaine-evoked calcium influx and neuropeptide release but not cytotoxicity in mouse sensory neurons

BACKGROUND: Local anaesthetics (LA) reduce neuronal excitability by inhibiting voltage-gated Na(+) channels. When applied at high concentrations in the direct vicinity of nerves, LAs can also induce relevant irritation and neurotoxicity via mechanisms involving an increase of intracellular Ca(2+). I...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Eberhardt, Mirjam, Stueber, Thomas, de la Roche, Jeanne, Herzog, Christine, Leffler, Andreas, Reeh, Peter W., Kistner, Katrin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5687772/
https://ncbi.nlm.nih.gov/pubmed/29141003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0188008
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