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Active metabolites of dipyrone induce a redox-dependent activation of the ion channels TRPA1 and TRPV1
INTRODUCTION: The nonopioid analgesic and antipyretic dipyrone (metamizol) is frequently used worldwide. Dipyrone is a prodrug, and the metabolites 4-N-methylaminoantipyrine (MAA) and 4-aminoantipyrine (AA) seem to induce analgesia and antipyresia in part by inhibiting cyclooxygenase. In mice, howev...
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| Publicado no: | Pain Rep |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Wolters Kluwer
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6749899/ https://ncbi.nlm.nih.gov/pubmed/31583344 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/PR9.0000000000000720 |
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