Reactive metabolites of acetaminophen activate and sensitize the capsaicin receptor TRPV1

The irritant receptor TRPA1 was suggested to mediate analgesic, antipyretic but also pro-inflammatory effects of the non-opioid analgesic acetaminophen, presumably due to channel activation by the reactive metabolites parabenzoquinone (pBQ) and N-acetyl-parabenzoquinonimine (NAPQI). Here we explored...

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Pubblicato in:Sci Rep
Autori principali: Eberhardt, Mirjam J., Schillers, Florian, Eberhardt, Esther M., Risser, Linus, de la Roche, Jeanne, Herzog, Christine, Echtermeyer, Frank, Leffler, Andreas
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5630573/
https://ncbi.nlm.nih.gov/pubmed/28986540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-13054-3
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