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Reactive metabolites of acetaminophen activate and sensitize the capsaicin receptor TRPV1
The irritant receptor TRPA1 was suggested to mediate analgesic, antipyretic but also pro-inflammatory effects of the non-opioid analgesic acetaminophen, presumably due to channel activation by the reactive metabolites parabenzoquinone (pBQ) and N-acetyl-parabenzoquinonimine (NAPQI). Here we explored...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5630573/ https://ncbi.nlm.nih.gov/pubmed/28986540 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-13054-3 |
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