Oxidation of methionine residues activates the high-threshold heat-sensitive ion channel TRPV2

Thermosensitive transient receptor potential (TRP) ion channels detect changes in ambient temperature to regulate body temperature and temperature-dependent cellular activity. Rodent orthologs of TRP vanilloid 2 (TRPV2) are activated by nonphysiological heat exceeding 50 °C, and human TRPV2 is heat-...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Fricke, Tabea C., Echtermeyer, Frank, Zielke, Johannes, de la Roche, Jeanne, Filipovic, Milos R., Claverol, Stéphane, Herzog, Christine, Tominaga, Makoto, Pumroy, Ruth A., Moiseenkova-Bell, Vera Y., Zygmunt, Peter M., Leffler, Andreas, Eberhardt, Mirjam J.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2019
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6883831/
https://ncbi.nlm.nih.gov/pubmed/31719194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1904332116
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