The General Anesthetic Propofol Excites Nociceptors by Activating TRPV1 and TRPA1 Rather than GABA(A) Receptors

Anesthetic agents can induce a paradox activation and sensitization of nociceptive sensory neurons and, thus, potentially facilitate pain processing. Here we identify distinct molecular mechanisms that mediate an activation of sensory neurons by 2,6-diisopropylphenol (propofol), a commonly used intr...

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Autors principals: Fischer, Michael J. M., Leffler, Andreas, Niedermirtl, Florian, Kistner, Katrin, Eberhardt, Mirjam, Reeh, Peter W., Nau, Carla
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
Matèries:
Molecular Biophysics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2966094/
https://ncbi.nlm.nih.gov/pubmed/20826794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.143958
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