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The General Anesthetic Propofol Excites Nociceptors by Activating TRPV1 and TRPA1 Rather than GABA(A) Receptors
Anesthetic agents can induce a paradox activation and sensitization of nociceptive sensory neurons and, thus, potentially facilitate pain processing. Here we identify distinct molecular mechanisms that mediate an activation of sensory neurons by 2,6-diisopropylphenol (propofol), a commonly used intr...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2966094/ https://ncbi.nlm.nih.gov/pubmed/20826794 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.143958 |
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