Swedish Alzheimer Mutation Induces Mitochondrial Dysfunction Mediated by HSP60 Mislocalization of Amyloid Precursor Protein (APP) and Beta-Amyloid

Alzheimer disease (AD) is a complex disorder that involves numerous cellular and subcellular alterations including impairments in mitochondrial homeostasis. To better understand the role of mitochondrial dysfunction in the pathogenesis of AD, we analyzed brains from clinically well-characterized hum...

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Autors principals: Walls, Ken Carlson, Coskun, Pinar, Gallegos-Perez, Jose Luis, Zadourian, Nineli, Freude, Kristine, Rasool, Suhail, Blurton-Jones, Mathew, Green, Kim Nicholas, LaFerla, Frank Michael
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
Matèries:
Molecular Bases of Disease
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436283/
https://ncbi.nlm.nih.gov/pubmed/22753410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.365890
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