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Aβ inhibits the proteasome and enhances amyloid and tau accumulation

The accumulation of misfolded protein aggregates is a common feature of numerous neurodegenerative disorders including Alzheimer disease (AD). Here, we examined the effects of different assembly states of amyloid beta (Aβ) on proteasome function. We find that Aβ oligomers, but not monomers, inhibit...

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Bibliografske podrobnosti
Main Authors: Tseng, Bertrand P., Green, Kim N., Chan, Julie L., Blurton-Jones, Mathew, LaFerla, Frank M.
Format: Artigo
Jezik:Inglês
Izdano: 2007
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2664168/
https://ncbi.nlm.nih.gov/pubmed/17544172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2007.04.014
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