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Aβ inhibits the proteasome and enhances amyloid and tau accumulation

The accumulation of misfolded protein aggregates is a common feature of numerous neurodegenerative disorders including Alzheimer disease (AD). Here, we examined the effects of different assembly states of amyloid beta (Aβ) on proteasome function. We find that Aβ oligomers, but not monomers, inhibit...

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Detaylı Bibliyografya
Asıl Yazarlar: Tseng, Bertrand P., Green, Kim N., Chan, Julie L., Blurton-Jones, Mathew, LaFerla, Frank M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2007
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2664168/
https://ncbi.nlm.nih.gov/pubmed/17544172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2007.04.014
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