Soluble Aβ Promotes Wild-Type Tau Pathology In Vivo

Growing evidence suggests that soluble Aβ species can drive Alzheimer disease (AD) pathogenesis by inducing a cascade of events including tau hyperphosphorylation, proteasome impairment, and synaptic dysfunction. However, these studies have relied largely on in vitro approaches to examine the role o...

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Detalhes bibliográficos
Main Authors: Chabrier, Meredith A., Blurton-Jones, Mathew, Agazaryan, Andranik A., Nerhus, Joy L., Martinez-Coria, Hilda, LaFerla, Frank M.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2012
Assuntos:
Brief Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3586232/
https://ncbi.nlm.nih.gov/pubmed/23197725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0172-12.2012
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