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Mifepristone alters APP processing to preclude Aβ and also reduces tau pathology
BACKGROUND: Increased circulating glucocorticoids are features of both aging and Alzheimer’s disease (AD), and increased glucocorticoids accelerate the accumulation of AD pathologies. Here we analyzed the effects of the glucocorticoid receptor antagonist mifepristone (RU-486) in the 3xTg-AD mouse mo...
Gorde:
| Egile Nagusiak: | , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2013
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3633722/ https://ncbi.nlm.nih.gov/pubmed/23312564 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2012.12.003 |
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