Mifepristone alters APP processing to preclude Aβ and also reduces tau pathology

BACKGROUND: Increased circulating glucocorticoids are features of both aging and Alzheimer’s disease (AD), and increased glucocorticoids accelerate the accumulation of AD pathologies. Here we analyzed the effects of the glucocorticoid receptor antagonist mifepristone (RU-486) in the 3xTg-AD mouse mo...

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Bibliographic Details
Main Authors: Baglietto-Vargas, David, Medeiros, Rodrigo, Martinez-Coria, Hilda, LaFerla, Frank M, Green, Kim N
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3633722/
https://ncbi.nlm.nih.gov/pubmed/23312564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2012.12.003
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