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Genetically Altering Aβ Distribution from the Brain to the Vasculature Ameliorates Tau Pathology
The inheritance of the ε4 allele of the apolipoprotein E (apoE) gene is the major genetic risk factor for developing late‐onset Alzheimer disease. In transgenic mice overexpressing amyloid precursor protein (APP), replacing the endogenous mouse apoE gene with the human apolipoprotein E4 (apoE4) gene...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Blackwell Publishing Ltd
2008
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4072242/ https://ncbi.nlm.nih.gov/pubmed/18657136 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1750-3639.2008.00194.x |
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