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Lithium Reduces Tau Phosphorylation but Not Aβ or Working Memory Deficits in a Transgenic Model with Both Plaques and Tangles

Glycogen synthase kinase 3 (GSK-3) is a major kinase implicated in the pathogenesis of Alzheimer’s disease (AD), and reducing its activity may have therapeutic efficacy. Two variants exist, referred to as GSK-3α and GSK-3β. In addition to the latter’s well-described role in the phosphorylation of ta...

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Detalhes bibliográficos
Main Authors: Caccamo, Antonella, Oddo, Salvatore, Tran, Lana X., LaFerla, Frank M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1854961/
https://ncbi.nlm.nih.gov/pubmed/17456772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2007.061178
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