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Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology
Neurofibrillary tangles (NFTs) are composed of abnormal aggregates of the cytoskeletal protein tau. Together with amyloid β (Aβ) plaques and neuronal and synaptic loss, NFTs constitute the primary pathological hallmarks of Alzheimer disease (AD). Recent evidence also suggests that caspases are activ...
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| 出版年: | J Clin Invest |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Clinical Investigation
2004
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC437967/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15232619/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI20640 |
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