Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology

Neurofibrillary tangles (NFTs) are composed of abnormal aggregates of the cytoskeletal protein tau. Together with amyloid β (Aβ) plaques and neuronal and synaptic loss, NFTs constitute the primary pathological hallmarks of Alzheimer disease (AD). Recent evidence also suggests that caspases are activ...

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Hauptverfasser: Rissman, Robert A., Poon, Wayne W., Blurton-Jones, Mathew, Oddo, Salvatore, Torp, Reidun, Vitek, Michael P., LaFerla, Frank M., Rohn, Troy T., Cotman, Carl W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2004
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC437967/
https://ncbi.nlm.nih.gov/pubmed/15232619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200420640
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