Hepatoma Cells from Mice Deficient in Glycine N-Methyltransferase Have Increased RAS Signaling and Activation of Liver Kinase B1

BACKGROUND & AIMS: Patients with cirrhosis are at high risk for developing hepatocellular carcinoma (HCC), and their liver tissues have abnormal levels of adenosylmethionine (SAMe). Glycine N-methyltransferase (GNMT) catabolizes SAMe but its expression is downregulated in HCC cells. Mice that la...

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Main Authors: Martínez-López, Nuria, García-Rodríguez, Juan L, Varela-Rey, Marta, Gutiérrez, Virginia, Fernández-Ramos, David, Beraza, Naiara, Aransay, Ana M, Schlangen, Karin, Lozano, Juan Jose, Aspichueta, Patricia, Luka, Zigmund, Wagner, Conrad, Evert, Matthias, Calvisi, Diego F, Lu, Shelly C, Mato, José M, Martínez-Chantar, María L
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3429651/
https://ncbi.nlm.nih.gov/pubmed/22687285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2012.05.050
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