Fatty liver and fibrosis in glycine N-methyltransferase knockout mice is prevented by nicotinamide

Deletion of glycine N-methyltransferase (GNMT) in mice, the main gene involved in liver S-adenosylmethionine (SAMe) catabolism, leads to the hepatic accumulation of this molecule and the development of fatty liver and fibrosis. To demonstrate that the excess of hepatic SAMe is the main agent contrib...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Varela-Rey, Marta, Martínez-López, Nuria, Fernández-Ramos, David, Embade, Nieves, Calvisi, Diego F., Woodhoo, Aswhin, Rodríguez, Juan, Fraga, Mario F, Julve, Josep, Rodríguez-Millán, Elisabeth, Frades, Itziar, Torres, Luís, Luka, Zigmund, Wagner, Conrad, Esteller, Manel, Lu, Shelly C, Martínez-Chantar, M Luz, Mato, José M
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2921576/
https://ncbi.nlm.nih.gov/pubmed/20578266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.23639
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados