Fatty liver and fibrosis in glycine N-methyltransferase knockout mice is prevented by nicotinamide

Deletion of glycine N-methyltransferase (GNMT) in mice, the main gene involved in liver S-adenosylmethionine (SAMe) catabolism, leads to the hepatic accumulation of this molecule and the development of fatty liver and fibrosis. To demonstrate that the excess of hepatic SAMe is the main agent contrib...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Varela-Rey, Marta, Martínez-López, Nuria, Fernández-Ramos, David, Embade, Nieves, Calvisi, Diego F., Woodhoo, Aswhin, Rodríguez, Juan, Fraga, Mario F, Julve, Josep, Rodríguez-Millán, Elisabeth, Frades, Itziar, Torres, Luís, Luka, Zigmund, Wagner, Conrad, Esteller, Manel, Lu, Shelly C, Martínez-Chantar, M Luz, Mato, José M
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2010
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2921576/
https://ncbi.nlm.nih.gov/pubmed/20578266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.23639
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