Loss of the Glycine N-Methyltransferase Gene Leads to Steatosis and Hepatocellular Carcinoma in Mice

Glycine N-methyltransferase (GNMT) is the main enzyme responsible for catabolism of excess hepatic S-adenosylmethionine (SAMe). GNMT is absent in hepatocellular carcinoma (HCC), messenger RNA (mRNA) levels are significantly lower in livers of patients at risk of developing HCC, and GNMT has been pro...

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Main Authors: Luz Martínez-Chantar, M., Vázquez-Chantada, Mercedes, Ariz, Usue, Martínez, Nuria, Varela, Marta, Luka, Zigmund, Capdevila, Antonieta, Rodríguez, Juan, Aransay, Ana M., Matthiesen, Rune, Yang, Heping, Calvisi, Diego F., Esteller, Manel, Fraga, Mario, Lu, Shelly C., Wagner, Conrad, Mato, José M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2405897/
https://ncbi.nlm.nih.gov/pubmed/18318442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.22159
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