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Tau promotes neurodegeneration via DRP1 mislocalization in vivo

Mitochondrial abnormalities have been documented in Alzheimer’s disease and related neurodegenerative disorders, but the causal relationship between mitochondrial changes and neurodegeneration, as well as the specific mechanisms promoting mitochondrial dysfunction, are not clear. Here we find that e...

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Hlavní autoři: DuBoff, Brian, Götz, Jürgen, Feany, Mel B.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3428596/
https://ncbi.nlm.nih.gov/pubmed/22920254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2012.06.026
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