Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration

The microtubule-associated protein tau accumulates in Alzheimer’s and other fatal dementias, which manifest when forebrain neurons die. Recent advances in understanding these disorders indicate that brain dysfunction precedes neurodegeneration, but the role of tau is unclear. Here, we show that earl...

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Autores principales: Hoover, Brian R., Reed, Miranda N., Su, Jianjun, Penrod, Rachel D., Kotilinek, Linda A., Grant, Marianne K., Pitstick, Rose, Carlson, George A., Lanier, Lorene M., Yuan, Li-Lian, Ashe, Karen H., Liao, Dezhi
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3026458/
https://ncbi.nlm.nih.gov/pubmed/21172610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2010.11.030
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