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Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration
The microtubule-associated protein tau accumulates in Alzheimer’s and other fatal dementias, which manifest when forebrain neurons die. Recent advances in understanding these disorders indicate that brain dysfunction precedes neurodegeneration, but the role of tau is unclear. Here, we show that earl...
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| 主要な著者: | , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3026458/ https://ncbi.nlm.nih.gov/pubmed/21172610 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2010.11.030 |
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