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Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration
The microtubule-associated protein tau accumulates in Alzheimer’s and other fatal dementias, which manifest when forebrain neurons die. Recent advances in understanding these disorders indicate that brain dysfunction precedes neurodegeneration, but the role of tau is unclear. Here, we show that earl...
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| Huvudupphovsmän: | , , , , , , , , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2010
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3026458/ https://ncbi.nlm.nih.gov/pubmed/21172610 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2010.11.030 |
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