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Mechanical injuries of neurons induce tau mislocalization to dendritic spines and tau-dependent synaptic dysfunction
Chronic traumatic encephalopathy (CTE) is associated with repeated traumatic brain injuries (TBI) and is characterized by cognitive decline and the presence of neurofibrillary tangles (NFTs) of the protein tau in patients’ brains. Here we provide direct evidence that cell-scale mechanical deformatio...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7682580/ https://ncbi.nlm.nih.gov/pubmed/33139536 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2008306117 |
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