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The Major G-Quadruplex Formed in the Human Platelet-Derived Growth Factor Receptor β (PDGFR-β) Promoter Adopts a Novel Broken-Strand Structure in K(+) Solution
Overexpression of PDGFR-β has been associated with cancers, vascular and fibrotic disorders. PDGFR-β has become an attractive target for the treatment of cancers and fibrotic disorders. DNA G-quadruplexes formed in GC-rich nuclease hypersensitivity element (NHE) of the human PDGFR-β gene promoter ha...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3428200/ https://ncbi.nlm.nih.gov/pubmed/22866911 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja305764d |
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