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Thermodynamic stability and folding kinetics of the major G-quadruplex and its loop-isomers formed in the Nuclease Hypersensitive Element in the human c-Myc promoter-Effect of loops and flanking segments on the stability of parallel-stranded intramolecular G-quadruplexes

Overexpression of the c-Myc proto-oncogene is associated with a broad spectrum of human cancers. The nuclease hypersensitivity element III(1) (NHE III(1)) of the c-Myc promoter can form transcriptionally active and silenced forms and the formation of DNA G-quadruplex structures has been shown to be...

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Bibliografiske detaljer
Main Authors: Hatzakis, Emmanuel, Okamoto, Keika, Yang, Danzhou
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964402/
https://ncbi.nlm.nih.gov/pubmed/20849082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi100946g
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