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Thermodynamic stability and folding kinetics of the major G-quadruplex and its loop-isomers formed in the Nuclease Hypersensitive Element in the human c-Myc promoter-Effect of loops and flanking segments on the stability of parallel-stranded intramolecular G-quadruplexes
Overexpression of the c-Myc proto-oncogene is associated with a broad spectrum of human cancers. The nuclease hypersensitivity element III(1) (NHE III(1)) of the c-Myc promoter can form transcriptionally active and silenced forms and the formation of DNA G-quadruplex structures has been shown to be...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2964402/ https://ncbi.nlm.nih.gov/pubmed/20849082 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi100946g |
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