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The Major G-Quadruplex Formed in the Human Platelet-Derived Growth Factor Receptor β (PDGFR-β) Promoter Adopts a Novel Broken-Strand Structure in K(+) Solution

Overexpression of PDGFR-β has been associated with cancers, vascular and fibrotic disorders. PDGFR-β has become an attractive target for the treatment of cancers and fibrotic disorders. DNA G-quadruplexes formed in GC-rich nuclease hypersensitivity element (NHE) of the human PDGFR-β gene promoter ha...

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Autors principals: Chen, Yuwei, Agrawal, Prashansa, Brown, Robert V., Hatzakis, Emmanuel, Hurley, Laurence, Yang, Danzhou
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3428200/
https://ncbi.nlm.nih.gov/pubmed/22866911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja305764d
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