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The Major G-Quadruplex Formed in the Human BCL-2 Proximal Promoter Adopts a Parallel Structure with a 13-nt Loop in K(+) Solution
[Image: see text] The human BCL-2 gene contains a 39-bp GC-rich region upstream of the P1 promoter that has been shown to be critically involved in the regulation of BCL-2 gene expression. Inhibition of BCL-2 expression can decrease cellular proliferation and enhance the efficacy of chemotherapy. He...
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| Gepubliceerd in: | J Am Chem Soc |
|---|---|
| Hoofdauteurs: | , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American Chemical
Society
2014
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| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4732354/ https://ncbi.nlm.nih.gov/pubmed/24450880 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja4118945 |
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