The Major G-Quadruplex Formed in the Human BCL-2 Proximal Promoter Adopts a Parallel Structure with a 13-nt Loop in K(+) Solution

[Image: see text] The human BCL-2 gene contains a 39-bp GC-rich region upstream of the P1 promoter that has been shown to be critically involved in the regulation of BCL-2 gene expression. Inhibition of BCL-2 expression can decrease cellular proliferation and enhance the efficacy of chemotherapy. He...

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發表在:J Am Chem Soc
Main Authors: Agrawal, Prashansa, Lin, Clement, Mathad, Raveendra I., Carver, Megan, Yang, Danzhou
格式: Artigo
語言:Inglês
出版: American Chemical Society 2014
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4732354/
https://ncbi.nlm.nih.gov/pubmed/24450880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja4118945
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