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Conformational selection in trypsin-like proteases
For over four decades, two competing mechanisms of ligand recognition – conformational selection and induced-fit - have dominated our interpretation of protein allostery. Defining the mechanism broadens our understanding of the system and impacts our ability to design effective drugs and new therape...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3423485/ https://ncbi.nlm.nih.gov/pubmed/22664096 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.sbi.2012.05.006 |
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