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Allostery in trypsin-like proteases suggests new therapeutic strategies

Trypsin-like proteases are a large family of enzymes responsible for digestion, blood coagulation, fibrinolysis, development, fertilization, apoptosis and immunity. A current paradigm posits that the irreversible transition from an inactive zymogen to the active protease form enables productive inte...

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Detalhes bibliográficos
Main Authors: Gohara, David W., Di Cera, Enrico
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3191250/
https://ncbi.nlm.nih.gov/pubmed/21726912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tibtech.2011.06.001
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