Inactivation of Spry2 accelerates AKT-driven hepatocarcinogenesis via activation of MAPK and PKM2 pathways

BACKGROUND & AIMS: Aberrant activation of the AKT oncogenic pathway and downregulation of the Sprouty 2 (Spry2) tumor suppressor gene are frequently observed molecular events in human hepatocarcinogenesis. The goal of the present study was to investigate the eventual biochemical and genetic cros...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Wang, Chunmei, Delogu, Salvatore, Ho, Coral, Lee, Susie A., Gui, Bing, Jiang, Lijie, Ladu, Sara, Cigliano, Antonio, Dombrowski, Frank, Evert, Matthias, Calvisi, Diego F., Chen, Xin
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3423481/
https://ncbi.nlm.nih.gov/pubmed/22617155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2012.04.026
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi