Inactivation of Spry2 accelerates AKT-driven hepatocarcinogenesis via activation of MAPK and PKM2 pathways

BACKGROUND & AIMS: Aberrant activation of the AKT oncogenic pathway and downregulation of the Sprouty 2 (Spry2) tumor suppressor gene are frequently observed molecular events in human hepatocarcinogenesis. The goal of the present study was to investigate the eventual biochemical and genetic cros...

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Bibliographische Detailangaben
Hauptverfasser: Wang, Chunmei, Delogu, Salvatore, Ho, Coral, Lee, Susie A., Gui, Bing, Jiang, Lijie, Ladu, Sara, Cigliano, Antonio, Dombrowski, Frank, Evert, Matthias, Calvisi, Diego F., Chen, Xin
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3423481/
https://ncbi.nlm.nih.gov/pubmed/22617155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2012.04.026
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