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AKT and N-Ras co-activation in the mouse liver promotes rapid carcinogenesis via mTORC1, FOXM1/SKP2, and c-Myc pathways

Activation of v-akt murine thymoma viral oncogene homolog (AKT) and Ras pathways is often implicated in carcinogenesis. However, the oncogenic cooperation between these two cascades in relationship to hepatocellular carcinoma (HCC) development remains undetermined. To investigate this issue, we gene...

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Bibliographische Detailangaben
Hauptverfasser: Ho, Coral, Wang, Chunmei, Mattu, Sandra, Destefanis, Giulia, Ladu, Sara, Delogu, Salvatore, Armbruster, Julia, Fan, Lingling, Lee, Susie A., Jiang, Lijie, Dombrowski, Frank, Evert, Matthias, Chen, Xin, Calvisi, Diego F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3269553/
https://ncbi.nlm.nih.gov/pubmed/21993994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.24736
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