AKT and N-Ras co-activation in the mouse liver promotes rapid carcinogenesis via mTORC1, FOXM1/SKP2, and c-Myc pathways

Activation of v-akt murine thymoma viral oncogene homolog (AKT) and Ras pathways is often implicated in carcinogenesis. However, the oncogenic cooperation between these two cascades in relationship to hepatocellular carcinoma (HCC) development remains undetermined. To investigate this issue, we gene...

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Hauptverfasser: Ho, Coral, Wang, Chunmei, Mattu, Sandra, Destefanis, Giulia, Ladu, Sara, Delogu, Salvatore, Armbruster, Julia, Fan, Lingling, Lee, Susie A., Jiang, Lijie, Dombrowski, Frank, Evert, Matthias, Chen, Xin, Calvisi, Diego F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3269553/
https://ncbi.nlm.nih.gov/pubmed/21993994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.24736
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