AKT and N-Ras co-activation in the mouse liver promotes rapid carcinogenesis via mTORC1, FOXM1/SKP2, and c-Myc pathways

Activation of v-akt murine thymoma viral oncogene homolog (AKT) and Ras pathways is often implicated in carcinogenesis. However, the oncogenic cooperation between these two cascades in relationship to hepatocellular carcinoma (HCC) development remains undetermined. To investigate this issue, we gene...

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Detalhes bibliográficos
Main Authors: Ho, Coral, Wang, Chunmei, Mattu, Sandra, Destefanis, Giulia, Ladu, Sara, Delogu, Salvatore, Armbruster, Julia, Fan, Lingling, Lee, Susie A., Jiang, Lijie, Dombrowski, Frank, Evert, Matthias, Chen, Xin, Calvisi, Diego F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3269553/
https://ncbi.nlm.nih.gov/pubmed/21993994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.24736
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