Increased lipogenesis, induced by AKT-mTORC1-RPS6 signaling, promotes development of human hepatocellular carcinoma

BACKGROUND & AIMS: De novo lipogenesis is believed to be involved in oncogenesis. We investigated the role of aberrant lipid biosynthesis in pathogenesis of human hepatocellular carcinoma (HCC). METHODS: We evaluated the expression of enzymes that regulate lipogenesis in human normal liver tissu...

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Detalhes bibliográficos
Main Authors: Calvisi, Diego F., Wang, Chunmei, Ho, Coral, Ladu, Sara, Lee, Susie A., Mattu, Sandra, Destefanis, Giulia, Delogu, Salvatore, Zimmermann, Antje, Ericsson, Johan, Brozzetti, Stefania, Staniscia, Tommaso, Chen, Xin, Dombrowski, Frank, Evert, Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3057329/
https://ncbi.nlm.nih.gov/pubmed/21147110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2010.12.006
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