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Synergistic role of Spry2 inactivation and c-Met upregulation in mouse and human hepatocarcinogenesis

Sprouty2 (Spry2), a negative feedback regulator of the Ras/MAPK pathway, is frequently downregulated in human hepatocellular carcinoma (HCC). In the present investigation, we tested the hypothesis that loss of Spry2 cooperates with unconstrained activation of the c-Met protooncogene to induce hepato...

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Hlavní autoři: Lee, Susie A., Ladu, Sara, Evert, Matthias, Dombrowski, Frank, De Murtas, Valentina, Chen, Xin, Calvisi, Diego F.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2920762/
https://ncbi.nlm.nih.gov/pubmed/20683950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.23681
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