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Synergistic role of Spry2 inactivation and c-Met upregulation in mouse and human hepatocarcinogenesis
Sprouty2 (Spry2), a negative feedback regulator of the Ras/MAPK pathway, is frequently downregulated in human hepatocellular carcinoma (HCC). In the present investigation, we tested the hypothesis that loss of Spry2 cooperates with unconstrained activation of the c-Met protooncogene to induce hepato...
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| Asıl Yazarlar: | , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2010
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2920762/ https://ncbi.nlm.nih.gov/pubmed/20683950 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.23681 |
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