Lack of toxicity of a STAT3 decoy oligonucleotide

BACKGROUND: STAT3 overexpression has been detected in several cancers including head and neck squamous cell carcinoma (HNSCC). Previous studies using intratumoral administration of a STAT3 decoy oligonucleotide that abrogates STAT3-mediated gene transcription in preclinical cancer models have demons...

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Autori principali: Sen, Malabika, Tosca, Patricia J., Zwayer, Christa, Ryan, Michael J., Johnson, Jerry D., Knostman, Katherine A. B., Giclas, Patricia C., Peggins, James O., Tomaszewski, Joseph E., McMurray, Timothy P., Li, Changyou, Leibowitz, Michael S., Ferris, Robert L., Gooding, William E., Thomas, Sufi M., Johnson, Daniel E., Grandis, Jennifer R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422883/
https://ncbi.nlm.nih.gov/pubmed/18766340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-008-0823-6
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